SELECTED PUBLICATIONS

• Young, K. Starling, N. Sadanandam, A. (2020). The molecular biology of pancreatic neuroendocrine neoplasms: Challenges and translational opportunities. Seminars in cancer biology, Vol.61, pp. 132-138.
• Woolston, A. Khan, K. Spain, G. Barber, L. Griffiths, B. Gonzalez-Exposito, R. Hornsteiner, L. Punta, M. Patil, Y. Newey, A. Mansukhani, S. Davies, M. Furness, A. Sclafani, F. Peckitt, C. Jimanez, M. Kouvelakis, K. Ranftl, R. Begum, R. Rana, I. Thomas, J. Bryant, A. Quezada, S. Wotherspoon, A. Khan, N. Fotiadis, N. Marafioti, T. Powles, T. Lise, S. Calvo, F. Guettler, S. von Loga, K. Rao, S. Watkins, D. Starling, N. Chau, I. Sadanandam, A. Cunningham, D. Gerlinger, M. Genomic and transcriptomic determinants of therapy resistance and immune landscape evolution during anti-EGFR treatment in colorectal cancer. Cancer cell, Vol. 36 (1), pp. 35-50
• Fontana, E. Eason, K. Cervantes, A. Salazar, R. Sadanandam, A. (2019). Context matters—consensus molecular subtypes of colorectal cancer as biomarkers for clinical trials. Annals of oncology, Vol.30 (4), pp. 520-527.
• Neuzillet, C. Tijeras‐Raballand, A. Ragulan, C. Cros, J. Patil, Y. Martinet, M. Erkan, M. Kleeff, J. Wilson, J. Apte, M. Tosolini, M. Wilson, A.S. Delvecchio, F.R. Bousquet, C. Paradis, V. Hammel, P. Sadanandam, A. Kocher, H.M. (2019). Inter‐ and intra‐tumoural heterogeneity in cancer‐associated fibroblasts of human pancreatic ductal adenocarcinoma. The journal of pathology, Vol.248 (1), pp. 51-65.
• Nyamundanda, G. Fontana, E. Sadanandam, A. (2019). Is the tumour microenvironment a critical prognostic factor in early-stage colorectal cancer?. Annals of oncology, Vol.30 (10), pp. 1538-1540.
• Ragulan, C. Eason, K. Fontana, E. Nyamundanda, G. Tarazona, N. Patil, Y. Poudel, P. Lawlor, R.T. Del Rio, M. Koo, S.-. Tan, W.-. Sclafani, F. Begum, R. Teixeira Mendes, L.S. Martineau, P. Scarpa, A. Cervantes, A. Tan, I.B. Cunningham, D. Sadanandam, A. (2019). Analytical Validation of Multiplex Biomarker Assay to Stratify Colorectal Cancer into Molecular Subtypes. Scientific Reports, Vol.9 (1).
• Poudel, P. Nyamundanda, G. Patil, Y. Cheang, M.C. Sadanandam, A. (2019). Heterocellular gene signatures reveal luminal-A breast cancer heterogeneity and differential therapeutic responses. Npj Breast Cancer, Vol.5 (1).
• Smyth, E.C. Nyamundanda, G. Cunningham, D. Fontana, E. Ragulan, C. Tan, I.B. Lin, S.J. Wotherspoon, A. Nankivell, M. Fassan, M. Lampis, A. Hahne, J.C. Davies, A.R. Lagergren, J. Gossage, J.A. Maisey, N. Green, M. Zylstra, J.L. Allum, W.H. Langley, R.E. Tan, P. Valeri, N. Sadanandam, A. (2018). A seven-Gene Signature assay improves prognostic risk stratification of perioperative chemotherapy treated gastroesophageal cancer patients from the MAGIC trial. Annals of oncology, Vol.29 (12), pp. 2356-2362.
• Vlachogiannis, G. Hedayat, S. Vatsiou, A. Jamin, Y. Fernandez Mateos, J. Khan, K. Lampis, A. Eason, K. Burke, R. Rata, M. Koh, D.-. Tunariu, N. Collins, D. Hulkki, S. Ragulan, C. Spiteri Sagastume, I. Moorcraft, S.Y. Chau, I. Rao, S. Watkins, D. Fotiadis, N. Bali, M. Darvish Damavandi, M. Lote, H. Eltahir, Z. Smyth, L. Begum, R. Clarke, P. Hahne, J. Dowsett, M. De Bono, J. Workman, P. Sadanandam, A. Eccles, S. Starling, N. Braconi, C. Sottoriva, A. Robinson, S. Cunningham, D. Valeri, N. Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science, Vol.359(6378), pp. 920-926.
• Heindl, A. Khan, A.M. Rodrigues, D.N. Eason, K. Sadanandam, A. Orbegoso, C. Punta, M. Sottoriva, A. Lise, S. Banerjee, S. Yuan, Y. (2018). Microenvironmental niche divergence shapes BRCA1-dysregulated ovarian cancer morphological plasticity. Nature communications, Vol.9 (1).
• Eason, K. Nyamundanda, G. Sadanandam, A. (2018). polyClustR: defining communities of reconciled cancer subtypes with biological and prognostic significance. BMC Bioinformatics, Vol.19, pp. 182:1-182:1.
• Bijlsma, M.F. Sadanandam, A. Tan, P. Vermeulen, L. (2017). Molecular subtypes in cancers of the gastrointestinal tract. Nature Reviews Gastroenterology & Hepatology, Vol.14 (6), pp. 333-342.
• Nyamundanda, G. Poudel, P. Patil, Y. Sadanandam, A. (2017). A Novel Statistical Method to Diagnose, Quantify and Correct Batch Effects in Genomic Studies. Scientific Reports, Vol.7 (1).
• Sadanandam, A. Wullschleger, S. Lyssiotis, C.A. Grotzinger, C. Barbi, S. Bersani, S. Korner, J. Wafy, I. Mafficini, A. Lawlor, R.T. Simbolo, M. Asara, J.M. Blaker, H. Cantley, L.C. Wiedenmann, B. Scarpa, A. Hanahan, D. (2015). A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics. Cancer Discovery, Vol.5 (12), pp. 1296-1313.
• Guinney, J. Dienstmann, R. Wang, X. de Reyniès, A. Schlicker, A. Soneson, C. Marisa, L. Roepman, P. Nyamundanda, G. Angelino, P. Bot, B.M. Morris, J.S. Simon, I.M. Gerster, S. Fessler, E. De Sousa E Melo, F. Missiaglia, E. Ramay, H. Barras, D. Homicsko, K. Maru, D. Manyam, G.C. Broom, B. Boige, V. Perez-Villamil, B. Laderas, T. Salazar, R. Gray, J.W. Hanahan, D. Tabernero, J. Bernards, R. Friend, S.H. Laurent-Puig, P. Medema, J.P. Sadanandam, A. Wessels, L. Delorenzi, M. Kopetz, S. Vermeulen, L. Tejpar, S. (2015). The consensus molecular subtypes of colorectal cancer. Nature Medicine, Vol.21 (11), pp. 1350-1356.
• Kapoor, A. Yao, W. Ying, H. Hua, S. Liewen, A. Wang, Q. Zhong, Y. Wu, C.-. Sadanandam, A. Hu, B. Chang, Q. Chu, G.C. Al-Khalil, R. Jiang, S. Xia, H. Fletcher-Sananikone, E. Lim, C. Horwitz, G.I. Viale, A. Pettazzoni, P. Sanchez, N. Wang, H. Protopopov, A. Zhang, J. Heffernan, T. Johnson, R.L. Chin, L. Wang, Y.A. Draetta, G. DePinho, R.A. (2014). Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell, Vol.158 (1), pp. 185-197.
• Sadanandam, A. Wang, X. de Sousa E Melo, F. Gray, J.W. Vermeulen, L. Hanahan, D. Medema, J.P. (2014). Reconciliation of classification systems defining molecular subtypes of colorectal cancer: interrelationships and clinical implications. Cell cycle, Vol.13 (3), pp. 353-357.
• Sadanandam, A. Lyssiotis, C.A. Homicsko, K. Collisson, E.A. Gibb, W.J. Wullschleger, S. Ostos, L.C. Lannon, W.A. Grotzinger, C. Del Rio, M. Lhermitte, B. Olshen, A.B. Wiedenmann, B. Cantley, L.C. Gray, J.W. Hanahan, D. (2013). A colorectal cancer classification system that associates cellular phenotype and responses to therapy. Nature Medicine, Vol.19 (5), pp. 619-625.
• Heiser, L.M. Sadanandam, A. Kuo, W.-. Benz, S.C. Goldstein, T.C. Ng, S. Gibb, W.J. Wang, N.J. Ziyad, S. Tong, F. Bayani, N. Hu, Z. Billig, J.I. Dueregger, A. Lewis, S. Jakkula, L. Korkola, J.E. Durinck, S. Pepin, F. Guan, Y. Purdom, E. Neuvial, P. Bengtsson, H. Wood, K.W. Smith, P.G. Vassilev, L.T. Hennessy, B.T. Greshock, J. Bachman, K.E. Hardwicke, M.A. Park, J.W. Marton, L.J. Wolf, D.M. Collisson, E.A. Neve, R.M. Mills, G.B. Speed, T.P. Feiler, H.S. Wooster, R.F. Haussler, D. Stuart, J.M. Gray, J.W. Spellman, P.T. (2012). Subtype and pathway specific responses to anticancer compounds in breast cancer. PNAS, Vol.109 (8), pp. 2724-2729.
• Sadanandam, A. Sidhu, S.S. Wullschleger, S. Singh, S. Varney, M.L. Yang, C.-. Ashour, A.E. Batra, S.K. Singh, R.K. (2012). Secreted semaphorin 5A suppressed pancreatic tumour burden but increased metastasis and endothelial cell proliferation. Br j cancer, Vol.107 (3), pp. 501-507.
• Collisson, E.A. Sadanandam, A. Olson, P. Gibb, W.J. Truitt, M. Gu, S. Cooc, J. Weinkle, J. Kim, G.E. Jakkula, L. Feiler, H.S. Ko, A.H. Olshen, A.B. Danenberg, K.L. Tempero, M.A. Spellman, P.T. Hanahan, D. Gray, J.W. (2011). Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nature Medicine, Vol.17 (4), pp. 500-503.
• Sadanandam, A. Rosenbaugh, E.G. Singh, S. Varney, M. Singh, R.K. (2010). Semaphorin 5A promotes angiogenesis by increasing endothelial cell proliferation, migration, and decreasing apoptosis. Microvasc res, Vol.79 (1), pp. 1-9. show abstract
• Sadanandam, A. Varney, M.L. Singh, S. Ashour, A.E. Moniaux, N. Deb, S. Lele, S.M. Batra, S.K. Singh, R.K. (2010). High gene expression of semaphorin 5A in pancreatic cancer is associated with tumor growth, invasion and metastasis. Int j cancer, Vol.127 (6), pp. 1373-1383.

For complete list https://www.icr.ac.uk/our-research/researchers-and-teams/dr-anguraj-sadanandam/publications